Migraine is one of the most common neurological disorders, affecting nearly everyone at least once in their lifetime. Globally, medical students experience a high prevalence of migraines. This study aimed to investigate the relationship between the use of digital learning devices and migraine occurrence among medical students at King Abdulaziz University (KAU) in Jeddah, Saudi Arabia. A cross-sectional study was conducted with 398 male and female students in different academic years at the Faculty of Medicine of KAU. Data were collected through a structured and closed-ended questionnaire. Findings showed that more than half of the participants (52.5%) had experienced migraines at some point in their lives. Key migraine-associated factors included female gender (60.8%), school days (90.9%), a positive family history (76.6%), adolescence (54.1%), studying through electronic sources (52.2%), and screen exposure exceeding four hours per day (61.3%). A significant correlation was observed between the incidence of migraine and factors such as family history, gender, electronic study sources, duration of screen exposure, and adolescence. The study concluded that migraines among medical students could be related to prolonged use of digital study tools, such as laptops, computers, and tablets, which leads to extended screen exposure.