Regional policy consists of a range of measures and tools aimed at addressing and reducing economic disparities between regions. It is a crucial aspect of a country’s macroeconomic strategy and is implemented in conjunction with sector-specific, structural, and urban policies. This study examines the role of entrepreneurial support in the creative industries across regional, national, and local levels, focusing on small and medium-sized enterprises (SMEs) and other entities that influence the business climate and the growth of the creative sectors, especially advertising, in the Žilina region. The aim is to assess the current landscape of support for entrepreneurial ventures in the creative industry. The research evaluates data collected from advertising businesses in the Žilina region, a central component of the creative sector. A questionnaire survey was conducted with advertising agencies in the area, and based on the results, recommendations will be made to strengthen business development in the advertising industry at different levels.